Single-cell & Spatial Omics for Systems Biomedicine

“A difference, to be a difference, must make a difference.”

-Gertrude Stein

Rong Fan

Dr. Rong Fan is the Harold Hodgkinson Professor of Biomedical Engineering at Yale University and Professor of Pathology at Yale School of Medicine. He received a Ph.D. in Chemistry from the University of California at Berkeley, completed his postdoctoral training at California Institute of Technology, and then joined the faculty in the Department of Biomedical Engineering at Yale University in 2010. His latest contributions to science and engineering include the development of microfabricated devices for single-cell and spatial omics and the application to human cancer research, immunology, and immuno oncology. He developed a microdevice for simultaneous measurement of 42 immune effector proteins in single cells at high throughput, which remains the highest multiplexing to date for a single-cell protein secretion assay. This microdevice, called IsoCode, and the automation system, called IsoLight and IsoSpark, have been commercialized by IsoPlexis (NASDAQ: ISO) and used by more than 100 cancer centers and pharmaceutical companies including all top 15 major pharma in the world for evaluating cancer immunotherapies. His latest contribution to single-cell omics is the development of a first-of-its-kind technology for spatially resolved multi-omics sequencing of tissues at genome scale and cellular level. It demonstrated for the first time the mapping of whole transcriptome and hundreds of proteins pixel by pixel in a tissue section. He also developed spatial epigenome sequencing, which adds a new dimension to the emerging field of spatial omics. He is co-founder and scientific advisor of IsoPlexis, Singleron Biotechnologies, and AtlasXomics. He was on the SAB of Bio-Techne (NASDAQ: TECH) and chaired the Advisory Board of BioPath, a program launched to promote public science advocacy, education, and biotech workforce development in the Greater New Haven Area. He is the recipient of multiple awards including the NCI Howard Temin Career Transition Award, the NSF CAREER Award, and the Packard Fellowship for Science and Engineering. He has been elected to the American Institute for Medical and Biological Engineering (AIMBE), the Connecticut Academy of Science and Engineering (CASE), and the National Academy of Inventors (NAI).

Harold Hodgkinson Professor of Biomedical Engineering

Professor of Pathology, Yale School of Medicine

Email: rong.fan@yale.edu

Address: 55 Prospect St., New Haven, CT

Featured Publications

Di Zhang, Yanxiang Deng, Petra Kukanja, Eneritz Agirre, Marek Bartosovic, Mingze Dong, Cong Ma, Sai Ma, Graham Su, Shuozhen Bao, Yang Liu, Yang Xiao, Gorazd B. Rosoklija, Andrew J. Dwork, J. John Mann, Kam W. Leong, Maura Boldrini, Liya Wang, Maximilian Haeussler, Benjamin J. Raphael, Yuval Kluger, Gonçalo Castelo-Branco & Rong Fan

Nature, March 2023

Yang Liu, Marcello DiStasio, Graham Su, Hiromitsu Asashima, Archibald Enninful, Xiaoyu Qin, Yanxiang Deng, Jungmin Nam, Fu Gao, Pino Bordignon, Marco Cassano, Mary Tomayko, Mina Xu, Stephanie Halene, Joseph E. Craft, David Hafler & Rong Fan

Nature Biotechnology, February 2023

Funding Sources